• Mpox is a relatively rare disease caused by infection with the mpox virus, which is related to the smallpox virus. While less severe and much less contagious than smallpox, mpox can be a serious illness and seeing a doctor right away is important. 
  • Mpox spreads from infected humans, animals, and materials contaminated with the virus but primarily through close, personal, skin-to-skin contact with people who have mpox symptoms, such as rash and sores. 
  • Having sex or close physical contact with multiple people can put you at higher risk for monkeypox if it is spreading in the community.
  • It appears as a distinctive rash or sores on the skin anywhere on the body, especially in the genital area. It often begins as flu-like symptoms.
  • It is possible that pets could become infected or contaminated with the virus through close contact with an infected person and spread the virus to others.
  • We are working with state and federal agencies to monitor for monkeypox, and to help control the spread of the virus.

Here are some images* of what mpox can look like (click on image to enlarge):

* “Mpox rash” by NHS England High Consequence Infectious Diseases Network

  • Cover exposed skin in crowds
  • Don't share bedding or clothing with others
  • Talk to close physical and sexual contacts about their general health like recent rashes or sores
  • Stay aware if traveling to countries where there are outbreaks

Avoid: 

  • Direct skin-to-skin contact with the sores and scabs of people with mpox
  • Direct contact with body fluids of people with mpox, such as drainage from skin sores or saliva that was in contact with mouth sores
  • Contact with the respiratory secretions of people with mpox, such as saliva, during prolonged face-to-face contact or during intimate physical contact, such as kissing, cuddling, or sex
  • Touching items (such as bedding, towels, clothing, cups and utensils) that previously touched the sores or body fluids of people with mpox
  • For more information, visit Mpox Questions & Answers
  • Cover the area of the rash with clean, dry, loose-fitting clothing
  • Wear a well-fitted mask
  • Avoid skin-to-skin, or close contact with others
  • Help to protect friends, family and sex partners by talking with your medical provider and public health worker(s). 
  • See the CDC webpage Pets in the Home for information about what do if you have a pet
  • If you do not have healthcare provider or coverage, contact (831) 454-4114

Screen regularly for sexually transmitted infections. Syphilis and herpes are much more common than Mpox – they appear similar and should be treated too.

Mpox Vaccine

The Jynneos vaccine is for preventative use only and is a two-dose vaccine that is administered 28 days apart and has been approved by the U.S Food and Drug Administration for safe and effective monkeypox prevention.

We are working with healthcare systems to expand the locations of vaccines to their members and patients, while ensuring an equitable distribution to people who are uninsured, disconnected from care, or are from underserved communities.

While there is currently adequate vaccine supply, vaccine providers can offer vaccine to any patients who MAY be at risk. Persons who request vaccination should receive it without having to attest to specific risk factors. For complete guidelines, visit: CDPH, Considerations for Mpox Vaccination in California (11/15/2022).

How to Access Vaccine

Public Health is working closely with health care partners to offer the Jynneos vaccine.

Contact your healthcare provider to find out if you’re eligible to receive the Jynneos vaccine and schedule an appointment. If you’re uninsured and need support finding a Jynneos vaccine appointment, please email immunizations@santacruzcounty.us.

For Sutter/PAMF patients only:

Eligible patients can schedule a vaccine appointment by calling (833) 437-1830, Monday – Friday, 7:00 am – 6:00 pm. Appointment availability remains limited due to supply. Additional appointments will open as vaccine supply increases. For additional information and updates, patients may visit the Sutter Health Mpox Webpage. If you are eligible and unable to get an appointment, please call your healthcare provider.

Vaccine Resources

Last updated: 06/01/23

5/30/23

California Department of Public Health (CDPH) Dear Colleague Letter

This letter is a call to action to Californian health care providers to remain vigilant in mpox prevention, recognition, and testing, especially during the upcoming 2023 spring and summer season as people gather for festivals and events, including LGBTQ Pride Month in June.

5/15/23

CDC Health Update: Potential Risk for New Mpox Cases

Healthcare providers (HCP) are urged to remain diligent for possible mpox cases and should refamiliarize themselves with mpox presentation, specimen collection, testing procedures, treatment options, and reporting.

4/4/23

CDPH Advisory: Updates on Identification, Laboratory Testing, Management and Treatment, and Vaccination for Mpox Virus Infection in California

It is highly important to test for HIV and other sexually transmitted infections (STIs) when testing for mpox and providing HIV and STI treatment as soon as possible for those who test positive.

10/18/22

Report all Suspect mpox Cases to Santa Cruz County Public Health.

  • All suspect mpox cases must be reported within 1 working day to Santa Cruz County Communicable Disease Control, preferably by email or fax.
  • Please submit a Confidential Morbidity Report form by email to HSACD@santacruzcounty.us or by fax to (831) 454-5049.
  • Please note, providers do not need to report contacts to cases or potential exposures to Santa Cruz County Public Health.

Diagnosis:

For patients presenting with concern for mpox infection:

Commercial Reference Labs. Mpox testing is now available through LabCorp, Quest, ARUP and other reference labs are rapidly developing capacity to test.

  • For most Santa Cruz County Healthcare providers a commercial reference laboratory will be the best option for streamlined Mpox testing and resulting.
  • Please check with the reference lab regarding their lab-specific submission forms and requirements for specimen collection, labeling, and transport.
  • There is no need to contact Santa Cruz County Public Health for approval to test at commercial laboratories, but providers must still report all suspect cases within 1 working day.

Santa Clara County Public Health Lab is still accepting specimens for monkeypox testing reserved for abnormal clusters of cases and severely ill individuals, and uninsured or underinsured patients where other testing options are not available. For Public Health Lab specific submission forms and requirements for specimen collection please reference the Mpox PHL Testing Guidance.

inforgraph image

There continues to be adequate vaccine supply. Vaccine providers can offer vaccine to any patients who may be at risk, and persons who request vaccination should receive it without having to attest to specific risk factors.

Storage, Handling, Expiration and Administration

People with suspected mpox should isolate while awaiting testing results and if confirmed positive, continue isolation until all lesions are healed or criteria are met per the CDPH Mpox Home Isolation Guidance for the General Public.

Supportive care and treatment of symptoms should be initiated for all patients with suspected mpox infection. This may include topical medicines or other clinical interventions to manage symptoms with particular focus on management of pain and pruritis. Please see NYC Health treatment guidance and CDC resources below.

Tecovirimat (also called TPOXX), an antiviral medication available through an expanded access Investigational New Drug (EA-IND) protocol for the treatment of mpox infection, is available—see ordering information below.

Providers should consider tecovirimat treatment for high-risk suspect cases who have pending lab testing results and suspect cases who are experiencing severe symptoms.

Antiviral treatment of mpox infection should be considered for people with severe infection, illness complications (including pain not controlled with supportive care), and risk factors for progression to severe infection (children <8 years of age, immunocompromised or pregnant people, or those with a history of atopic dermatitis or eczema). Antiviral treatment (such as with TPOXX) should not be considered a substitute for pain management.

CDC TPOXX Required Paperwork

Ordering TPOXX

To place an order for TPOXX, please fill out the linked TPOXX Resource Request Form and CDPH’s TPOXX Request and Data Collection Form and email it to immunizations@santacruzcounty.us. A member of our team will confirm receipt of your request and begin processing your order. Orders will be shipped directly to the address listed on your resource request form. Please note, the CDC required TPOXX paperwork must be completed within seven (7) days of TPOXX treatment initiation.